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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PAK3 Antibody   

PAK3 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75914
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 62310 Da
Additional Information
Gene ID 5063
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Other applications have not been tested.
Other Names PAK3 , PAK3beta , Beta-PAK , hPAK3 , MRX47 , MRX30 , bPAK , oligophrenin-3 , CDKN1A , OPHN3
Target/Specificity PAK3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) Protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPAK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAK3
Synonyms OPHN3
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.
Cellular Location Cytoplasm.
Tissue Location Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
Research Areas
Citations (0)

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The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal recognization, MAPK signaling, apoptotic signaling, control of phagocytes, NADPH oxidase and growth factor-induced neurite outgrowth. Research indicates that phosphorylation of serine 139 of PAK3 which is located in the kinase inhibitory domain, affects the kinase activity.

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$ 245.00
Cat# ABV10519
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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