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HAT-1 Antibody

Rabbit Polyclonal Antibody

     
  • WB - HAT-1  Antibody ABV10522-30
    Western blot analysis of HAT-1expression in Jurkat cell lysate.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9H7Z6
Other Accession NP_115564
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52403 Da
Additional Information
Gene ID 84148
Application & Usage Western blotting (1-2 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 50 kDa HAT-1 from samples of human, mouse and rat origins. Jurkat cell lysate can be used as a positive control.
Other Names HAT 1 , Histidine aminotransferase 1 , Histone acetyltransferase 1 , KAT1
Target/Specificity HAT1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsHAT-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT8
Synonyms MOF, MYST1
Function Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'.
Cellular Location Nucleus. Chromosome
Citations (0)
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Background

Histone acetyltransferases (HATs) have been implicated in a number of cellular functions including gene regulation, DNA synthesis, and repair. Histone acetyltransferases and deacetylases are, respectively, the enzymes devoted to the addition and removal of acetyl groups from lysine residues on the histone N-terminal tails. The enzymes exert fundamental roles in developmental processes and their deregulation has been linked to the progression of diverse human disorders, including cancer.

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Discontinued
Cat# ABV10522-30
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