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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MMP-12 Antibody   

MMP-12 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P39900
Other Accession NP_002417
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 54002 Da
Additional Information
Gene ID 4321
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Mouse small intestine tissue lysate can be used as a positive control. The antibody recognizes the MMP-12 of human and mouse origins.
Other Names MMP12, MMP-12, MMP 12, matrix metalloproteinases 12, matrix metalloproteinases -12, matrix metalloproteinases 12
Target/Specificity MMP-12
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsMMP-12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP12
Synonyms HME
Function May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Found in alveolar macrophages but not in peripheral blood monocytes
Research Areas
Citations (0)

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The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration thro µgh the epidermal and vascular basement membranes in inflammatory disorders.

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$ 245.00
Cat# ABV10554
(40 western blots)
Availability: 5-7days
Bulk Size
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