MMP-12 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | P39900 |
Other Accession | NP_002417 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54002 Da |
Gene ID | 4321 |
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Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Mouse small intestine tissue lysate can be used as a positive control. The antibody recognizes the MMP-12 of human and mouse origins. |
Other Names | MMP12, MMP-12, MMP 12, matrix metalloproteinases 12, matrix metalloproteinases -12, matrix metalloproteinases 12 |
Target/Specificity | MMP-12 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol and 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | MMP-12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MMP12 |
---|---|
Synonyms | HME |
Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Found in alveolar macrophages but not in peripheral blood monocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration thro µgh the epidermal and vascular basement membranes in inflammatory disorders.
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