CRSP1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP |
---|---|
Primary Accession | Q15648 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 168478 Da |
Gene ID | 5469 |
---|---|
Application & Usage | Western blotting (1:500 – 1:2500 µg/ml), Immunoprecipitation. However, the optimal concentrations should be determined individually. |
Other Names | CRSP1, CRSP-1, Cofactor Required for Sp1 Transcriptional Activation 1, TRAP220, Thyroid Hormone Receptor-Associated Protein Complex Component, 220 kD, PPARBP, PPAR Binding Protein, DRIP205, Vitamin D Receptor Interacting Protein Complex Component, 205 kD, DRIP230, Vitamin D Receptor-Interacting Protein, 230 kD, TRIP2, Thyroid Receptor Interacting Protein 2, MED1, PBP, PPARGBP, RB18A |
Target/Specificity | CRSP1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | CRSP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MED1 |
---|---|
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1- mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). |
Cellular Location | Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3 |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CSP1/TRAP220 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
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