|Application ||WB, IP|
|Calculated MW||146205 Da|
|Application & Usage||Western blotting (1:500 – 1:2500) and Immunoprecipitation. HeLa nuclear extract can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the JLP of human and mouse origins. Reactivity to other species has not been tested.|
|Other Names||JLP, JLP1, JLP-1, JNK-associated leucine zipper protein 1, SPAG9|
|Formulation||100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||JLP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSS, KIAA0516, MAPK8IP4, SYD1|
|Function||The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation|
|Tissue Location||Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.|
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Provided below are standard protocols that you may find useful for product applications.
JLP (JNK-interacting leucine zipper protein) has been identified as a scaffolding protein that functions to position mitogen-activated protein kinases (MAPKs) into specific signaling modules so that successive phosphorylation events of the MAPK pathway can occur. JLP is also known as sperm associated antigen 9 (SPAG9) due to its abundant expression in testicular haploid germ cells.
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