|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||37660 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the mature form of Cathepsin L (25 kDa) from human, mouse and rat origins. Reactivity to other species has not been tested. Rat kidney tissue lysate can be used as a positive control.|
|Other Names||CTSL1 , CATL , CTSL , MEP , FLJ31037 , EC 18.104.22.168 , OTTHUMP00000063566|
|Target/Specificity||Cathepsin L (Cleaved)|
|Formulation||100 µg (0.5 mg/ml purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Cathepsin L (Cleaved) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important for the overall degradation of proteins in lysosomes. Procathepsin L is required for maximal stimulation of steroidogenesis by TIMP1.|
|Tissue Location||Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII|
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Provided below are standard protocols that you may find useful for product applications.
The cysteine proteases termed lysosomal cathepsins have long been tho µght to be primarily involved in end-stage protein breakdown within lysosomal compartments. Cathepsin L functions to regulate cell cycle progression thro µgh proteolytic processing of the CDP/Cux transcription factor.
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