|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||37660 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the mature form of Cathepsin L (25 kDa) from human, mouse and rat origins. Reactivity to other species has not been tested. Rat kidney tissue lysate can be used as a positive control.|
|Other Names||CTSL1 , CATL , CTSL , MEP , FLJ31037 , EC 184.108.40.206 , OTTHUMP00000063566|
|Target/Specificity||Cathepsin L (Cleaved)|
|Formulation||100 µg (0.5 mg/ml purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Cathepsin L (Cleaved) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important for the overall degradation of proteins in lysosomes. Procathepsin L is required for maximal stimulation of steroidogenesis by TIMP1.|
|Tissue Location||Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The cysteine proteases termed lysosomal cathepsins have long been tho µght to be primarily involved in end-stage protein breakdown within lysosomal compartments. Cathepsin L functions to regulate cell cycle progression thro µgh proteolytic processing of the CDP/Cux transcription factor.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.