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PI-8 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P50452 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42767 Da |
| Gene ID | 5271 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 40-45 kDa human PI-8. Reactivity to other species has not been tested. |
| Other Names | CAP2 , PI8 , SERPINB8 |
| Target/Specificity | PI-8 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 0.5 mg/ml purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 1% BSA, 30% glycerol and 0.02% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | PI-8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERPINB8 |
|---|---|
| Synonyms | PI8 |
| Function | Has an important role in epithelial desmosome-mediated cell- cell adhesion. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
High molecular weight serine protease inhibitors (serpins) are large superfamily of proteins, which bind to and inactivate serine proteinases. In 1995 Sprecher et al. cloned 2 novel serpins, termed PI8 and PI9, from human placenta cDNA library. Sequencing showed that PI8 encodes 376-amino acids. PI8 are localized to the cytoplasm of transfected cells and was able to form an SDS- complex. PI8 is implicated to inhibit furin enzymatic activity and plays a role in platelet-regulated pathophysiological responses.
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