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PI-8 Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P50452
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42767 Da
Additional Information
Gene ID 5271
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 40-45 kDa human PI-8. Reactivity to other species has not been tested.
Other Names CAP2 , PI8 , SERPINB8
Target/Specificity PI-8
Antibody Form Liquid
Appearance Colorless liquid
Formulation 0.5 mg/ml purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 1% BSA, 30% glycerol and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPI-8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINB8
Synonyms PI8
Function Has an important role in epithelial desmosome-mediated cell-cell adhesion.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

High molecular weight serine protease inhibitors (serpins) are large superfamily of proteins, which bind to and inactivate serine proteinases. In 1995 Sprecher et al. cloned 2 novel serpins, termed PI8 and PI9, from human placenta cDNA library. Sequencing showed that PI8 encodes 376-amino acids. PI8 are localized to the cytoplasm of transfected cells and was able to form an SDS- complex. PI8 is implicated to inhibit furin enzymatic activity and plays a role in platelet-regulated pathophysiological responses.

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$ 89.00
$ 245.00
Cat# ABV10571
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