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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SRC3 Antibody   

SRC3 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6Q9
Other Accession NP_858045.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 155293 Da
Additional Information
Gene ID 8202
Application & Usage Western blotting (1:500 – 1:2500) and Immunoprecipitation. However, the optimal concentrations should be determined individually. HeLa cell lysate can be used as a positive control. The antibody recognizes the SRC3 of human origin. Reactivity to other species has not been tested.
Other Names Steroid receptor coactivator 3, NCOA3, Nuclear Receptor Coactivator 3; TRAM1, Thyroid Hormone Receptor Activator Molecule 1; RAC3, Receptor-Associated Coactivator 3; AIB1, Amplified in Breast Cancer-1; pCIP, CBP-Interactin protein
Target/Specificity SRC3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSRC3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCOA3
Synonyms AIB1, BHLHE42, RAC3, TRAM1
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Cellular Location Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus
Tissue Location Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney
Research Areas
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Steroid receptor coactivator 3 (SRC3) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC3 is an oncogene that is reported to be amplified and/or overexpressed in breast and gastric cancer and stimulates AKT signaling and cell growth and tumorigenesis.

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$ 245.00
Cat# ABV10592
(40 western blots)
Availability: 5-7days
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