|Calculated MW||45626 Da|
|Application & Usage||Western blotting (1:500 – 1:2500). However, the optimal concentrations should be determined individually. HeLa and NIH3T3 cell lysates can be used as positive controls. The antibody recognizes the TRIP1(S µg1) of human and mouse origins. Reactivity to other species has not been tested.|
|Other Names||TRIP1, TRIP-1, Thyroid Receptor Interactor 1, TBP10, Tat-binding protein homolog 10, PSMC5, Proteasome (prosome, macropain) 26S Subunit, ATPase, 5, p45, p45/S µg, S µg1, S8|
|Formulation||100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TRIP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.|
|Cellular Location||Cytoplasm. Nucleus|
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Thyroid receptor interacting protein 1 (TRIP1) was originally identified as a protein that interacts with the thyroid receptor and is homologous to the yeast SUG1 protein, a transcriptional coactivator. It was later identified as an ATPase subunit of the 26S proteasome, a multicatalytic proteinase complex, and has also been shown to associate with nuclear receptors and transcription factors. TRIP1/SUG1 may function to regulate transcription factor abundance by targeting them for proteasome degradation.
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