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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CSE1 Antibody   

CSE1 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55060
Other Accession NP_001307
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 110417 Da
Additional Information
Gene ID 1434
Application & Usage Western blotting (1:1000 – 1:2500) and Immunoprecipitation. However, the optimal concentrations should be determined individually. HeLa cell lysate can be used as a positive control. The antibody recognizes the CSE1 of human and mouse origins. Reactivity to other species has not been tested.
Other Names CSE1, CSE-1, CSE1L, Chromosome Segregation 1-like, CAS, Cellular Apoptosis Susceptibility Protein, XPO2, XPO-2
Target/Specificity CSE1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCSE1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSE1L
Synonyms CAS, XPO2
Function Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Tissue Location Highly expressed in proliferating cells.
Research Areas
Citations (0)

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CSE1 function to re-export importin-alpha to the cytoplasm after it has transported nuclear localization signal (NLS) containing proteins to the nucleus. CSE1 is also thought to play a role in cell proliferation and the mitotic spindle checkpoint.

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$ 245.00
Cat# ABV10598
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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