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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RCH1 Antibody   

RCH1 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P52292
Other Accession NP_002257.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57862 Da
Additional Information
Gene ID 3838
Application & Usage Western blotting (1:500 – 1:2000) and Immunoprecipitation. However, the optimal concentrations should be determined individually. HeLa cell lysate can be used as a positive control. The antibody recognizes the RCH1 (KPNA2) of human origin. Reactivity to other species has not been tested.
Other Names RCH1, RAG cohort 1, KPNA2, Karyopherin alpha 2, IPOA1, Importin alpha 2, Pendulin, QIP2, SRP1alpha
Target/Specificity RCH1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsRCH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KPNA2
Synonyms RCH1, SRP1
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed ubiquitously.
Research Areas
Citations (0)

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The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex followed by translocation through the nuclear pore. RCH1 is an adaptor protein that recognizes the nuclear localization signal (NLS) on cargo and binds the karyopherin importin-beta receptor for nuclear import which is regulated by RanGTP.

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$ 245.00
Cat# ABV10599
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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