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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   Nectin-3/CD113 Antibody   

Nectin-3/CD113 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NQS3
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 61002 Da
Additional Information
Gene ID 25945
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~ 83 kDa Nectin-3 of mouse and rat origins. Reactivity to other species has not been tested.
Other Names Nectin3, Nectin 3, Poliovirus receptor-related protein 3, PVRL3, PVRL-3, PVRL 3, CDw113, CD113, PRR3, PRR-3
Target/Specificity Nectin
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-Nectin-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsNectin-3/CD113 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PVRL3
Synonyms PRR3
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Cellular Location Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Tissue Location Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines
Research Areas
Citations (0)

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Nectin is a cell-adhesion molecule that belongs to the immunoglobilin superfamily and is also known as the poliovirus receptor-related protein or PPR. Nectin family consists of Nectin 1 which expressed abundantly in the brain and Nectin 2 and 3 which are ubiquitously expressed in cells where cadherin are not expressed. Nectin-3 or PPR3 is a transmembrane protein that has three splicing variants: Nectin3α, Nectin 3β and Nectin 3g. Nectin-3 is mainly expressed in the testis and placental tissues and interacts in vivo with both long and short isoforms of afadin.

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$ 265.00
Cat# ABV10635
(40 western blots)
Availability: 5-7days
Bulk Size
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