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Sox-1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P53783 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39053 Da |
| Gene ID | 20664 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~ 43 kDa Sox-1 in samples of human and mouse origins. Reactivity to other species has not been tested. |
| Other Names | SOX1, SOX 1, sex determining region Y box 1, SRY, SRY-box containing gene 1 |
| Target/Specificity | Sox1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-Sox-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Sox-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sox1 |
|---|---|
| Synonyms | Sox-1 |
| Function | Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Mainly in the developing central nervous system. Expressed in developing urogenital ridge |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sox proteins are related to mammalian sex deternining gene that encodes DNA-binding protein. About 30 SOX family proteins have been identified. Sox-1 is a transcription factor that is found in the embryonic nervous system. Sox-1 maintains nueral cells in an undifferentiated state and has been used as a marker for neural stem cells.
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