|Reactivity||Human, Mouse, Rat|
|Calculated MW||39053 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~ 43 kDa Sox-1 in samples of human and mouse origins. Reactivity to other species has not been tested.|
|Other Names||SOX1, SOX 1, sex determining region Y box 1, SRY, SRY-box containing gene 1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-Sox-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Sox-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
|Tissue Location||Mainly in the developing central nervous system. Expressed in developing urogenital ridge|
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Provided below are standard protocols that you may find useful for product applications.
Sox proteins are related to mammalian sex deternining gene that encodes DNA-binding protein. About 30 SOX family proteins have been identified. Sox-1 is a transcription factor that is found in the embryonic nervous system. Sox-1 maintains nueral cells in an undifferentiated state and has been used as a marker for neural stem cells.
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