|Calculated MW||83869 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 60-100 kDa MPO from samples of human, mouse, and rat origins. Reactivity to other species has not been tested. |
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-MPO polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Myeloperoxidase (MPO) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.|
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Provided below are standard protocols that you may find useful for product applications.
Myeloperoxidase (MPO) is highly expressed in neutrophils and polymorphonuclear luekocytes. MPO is expressed as a dimer in regular neutrophils with a 140kDA. The glycoslated form of MPO has a molecular weight of 92kDa and when undergoes a final glycoslyation, MPO forms subunits of 60kDa and 12kDa. In recent studies, MPO was shown to be involved in the initiation and progression of cardiovascular disease.
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