|Reactivity||Human, Mouse, Rat|
|Calculated MW||99613 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). It detects a band between 70-100 kDa, corresponding to the molecular mass of Lipin-2. A lower band ~55 kDa can also be detected, presumably to be the cleavage fragment of Lipin-2.|
|Other Names||KIAA0249 , LPIN2|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Lipin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Translocates from cytosol to endoplasmic reticulum membrane with increasing levels of oleate|
|Tissue Location||Expressed at high level in liver and to some extend in lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Expressed also in circulating red blood cells and site of lymphopoiesis|
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Provided below are standard protocols that you may find useful for product applications.
Lipin 2 is a nuclear protein that belongs to the evolutionarily conserved Lipin family. Studies show that a mutation to human Lipin 2 is linked to autosomal dominant high grade myopia and Majeed syndrome.
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