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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FRS2 Antibody   

FRS2 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WU20
Other Accession NP_006645.3
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57029 Da
Additional Information
Gene ID 10818
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually.
Other Names FRS2 , FRS2A , FRS2alpha , SNT, SNT-1 , SNT
Target/Specificity FRS2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFRS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FRS2
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Cellular Location Endomembrane system. Note=Cytoplasmic, membrane-bound
Tissue Location Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis
Research Areas
Citations (0)

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Fibroblast growth factor receptor substrate 2 (FRS2) is a 70-90kDA member of the FSR family of lipid-anchored docking protein. FRS2 contains Grb2 binding sites, a myristylation sequence and a PTP domain. Activation of FGFR leads to tyrosine phosphorylation of FRS2 and the binding of phosphorylated FRS2 to GRB2/SOS complexes. Once phosphorylated, FRS2 recruits SH2 domain-containing proteins including Grb2 and SHP-2 mediating downstream signalling. FRS2 thus, acts as an intermediary between FGF and Trk receptors that links receptor tyrosine kinase to Ras/MAPK signaling pathway.

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$ 245.00
Cat# ABV10647
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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