|Calculated MW||23130 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects a 22 kDa rat NTAL/LAB. Other species have not been determined. |
|Other Names||HSPC046 , LAB , LAT2 , NTAL, WBSCR15, WBSCR5 , WSCR5|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||NATL/LAB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Lab, Ntal, Wbscr5|
|Function||Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.|
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Provided below are standard protocols that you may find useful for product applications.
Non-T cell Activation Linker (NTAL) is also known as linker for activation of B cells (LAB), is a transmembrane adaptor protein. NTAL is expressed in B cells, mast cells, monocytes and NK cells. When NTAL is tyrosine phosphorylated, it recruits signalling molecules such as Grb2, Gab2 and c-Cbl into receptor-signalling complexes. Mutation in the NTAL gene may cause Williams-Beuren syndrome, a rare genetic disorder.
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