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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LDLR Antibody   

LDLR Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01130
Reactivity Human, Mouse, Rat, Hamster, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 95376 Da
Additional Information
Gene ID 3949
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes mature LDLR (160 kDa), LDLR precursor (120 kDa) and LDLR monomer (~50 kDa).
Other Names FH , FHC , LDL receptor , LDLR , LDLR precursor
Target/Specificity LDLR
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-LDLR polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsLDLR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9
Research Areas
Citations (0)

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Low density lipoprotein receptors (LDLR) are cell surface glycoproteins that regulate LDL cholesterol by scavenging LDL from the blood. LDLR is characterized by a cluster of cysteine-rich class A repeats, EGF-like repeats, the O-linked s µgars domain and six YWTD or class B repeats. Mutations in the LDLR gene cause autosomal dominant disease such as familial hypercholesterolemia (FH) and atherosclerosis.

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$ 295.00
Cat# ABV10650
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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