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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   ECM Antibody   

ECM Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q61508
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Additional Information
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~61 kDa ECM-1 of human, mouse, and rat origins. Reactivity to other species has not been tested.
Other Names ECM1, extracellular matrix protein, extracellular matrix protein 1
Target/Specificity ECM
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-ECM-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsECM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ecm1
Function Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in the connective tissues surronding developing long bones, but not in the cartilage. The long isoform is expressed in a number of tissues including liver, heart and lungs. The short isoform is expressed in skin and cartilage- containing tissues such as tail and front paw. No expression is found in brain. EMBL; L33416; AAA37535.1; -; mRNA EMBL; AK153009; BAE31648.1; -; mRNA EMBL; AK153471; BAE32022.1; -; mRNA CCDS; CCDS17619.1; -. [Q61508-1] RefSeq; NP_031925.2; NM_007899.2. [Q61508-1] UniGene; Mm.3433; - ProteinModelPortal; Q61508; - IntAct; Q61508; 1 STRING; 10090.ENSMUSP00000112665; - iPTMnet; Q61508; - PhosphoSitePlus; Q61508; - SwissPalm; Q61508; - UniCarbKB; Q61508; - PaxDb; Q61508; - PeptideAtlas; Q61508; - PRIDE; Q61508; - Ensembl; ENSMUST00000117507; ENSMUSP00000112665; ENSMUSG00000028108. [Q61508-1] GeneID; 13601; - KEGG; mmu:13601; - UCSC; uc008qko.2; mouse. [Q61508-1] CTD; 1893; - MGI; MGI:103060; Ecm1 eggNOG; ENOG410IVN8; Eukaryota eggNOG; ENOG4111TGN; LUCA GeneTree; ENSGT00390000006215; - HOGENOM; HOG000112317; - HOVERGEN; HBG005561; - InParanoid; Q61508; - OMA; CCHYPPS; - OrthoDB; EOG091G0NAE; - PhylomeDB; Q61508; - TreeFam; TF330786; - Reactome; R-MMU-114608; Platelet degranulation PRO; PR:Q61508; - Proteomes; UP000000589; Chromosome 3 Bgee; ENSMUSG00000028108; - CleanEx; MM_ECM1; - ExpressionAtlas; Q61508; baseline and differential Genevisible; Q61508; MM GO; GO:0070062; C:extracellular exosome; ISO:MGI GO; GO:0031012; C:extracellular matrix; ISO:MGI GO; GO:0005615; C:extracellular space; IDA:MGI GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell GO; GO:0019899; F:enzyme binding; ISO:MGI GO; GO:0005134; F:interleukin-2 receptor binding; IPI:MGI GO; GO:0043236; F:laminin binding; ISO:MGI GO; GO:0002020; F:protease binding; ISO:MGI GO; GO:0008022; F:protein C-terminus binding; ISO:MGI GO; GO:0004871; F:signal transducer activity; ISO:MGI GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW GO; GO:0006954; P:inflammatory response; IMP:MGI GO; GO:0030502; P:negative regulation of bone mineralization; ISS:UniProtKB GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IDA:MGI GO; GO:0010466; P:negative regulation of peptidase activity; ISS:UniProtKB GO; GO:0001503; P:ossification; IEA:UniProtKB-KW GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:MGI GO; GO:2000404; P:regulation of T cell migration; IMP:MGI GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI GO; GO:0002828; P:regulation of type 2 immune response; IMP:MGI InterPro; IPR008605; ECM1 InterPro; IPR020858; Serum_albumin-like Pfam; PF05782; ECM1; 1 SUPFAM; SSF48552; SSF48552; 2 1: Evidence at protein level; Alternative splicing; Angiogenesis; Biomineralization; Complete proteome; Direct protein sequencing; Extracellular matrix; Glycoprotein; Mineral balance; Osteogenesis; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 19 CHAIN 20 559 Extracellular matrix protein 1 /FTId=PRO_0000021147 REPEAT 170 298 1 REPEAT 302 424 2 REGION 170 424 2 X approximate repeats MOD_RES 556 556 Phosphoserine {ECO:0000250|UniProtKB:Q62894} CARBOHYD 373 373 N-linked (GlcNAc...). CARBOHYD 463 463 N-linked (GlcNAc...) (high mannose) CARBOHYD 535 535 N-linked (GlcNAc...) (high mannose) VAR_SEQ 256 380 Missing (in isoform Short) /FTId=VSP_004230 CONFLICT 53 53 P -> L (in Ref. 1; AAA37535) CONFLICT 241 241 R -> P (in Ref. 1; AAA37535) CONFLICT 466 466 I -> V (in Ref. 1; AAA37535) SEQUENCE 559 AA; 62832 MW; F5282E5D7B78E696 CRC64; MGTVSRAALI LACLALASAA SEGAFKASDQ REMTPERLFQ HLHEVGYAAP PSPPQTRRLR VDHSVTSLHD PPLFEEQREV QPPSSPEDIP VYEEDWPTFL NPNVDKAGPA VPQEAIPLQK EQPPPQVHIE QKEIDPPAQP QEEIVQKEVK PHTLAGQLPP EPRTWNPARH CQQGRRGVWG HRLDGFPPGR PSPDNLKQIC LPERQHVIYG PWNLPQTGYS HLSRQGETLN VLETGYSRCC RCRSDTNRLD CLKLVWEDAM TQFCEAEFSV KTRPHLCCRL RGEERFSCFQ KEAPRPDYLL RPCPVHQNGM SSGPQLPFPP GLPTPDNVKN ICLLRRFRAV PRNLPATDAI QRQLQALTRL ETEFQRCCRQ GHNHTCTWKA WEGTLDGYCE RELAIKTHPH SCCHYPPSPA RDECFAHLAP YPNYDRDILT LDLSRVTPNL MGQLCGSGRV LSKHKQIPGL IQNMTIRCCE LPYPEQACCG EEEKLAFIEN LCGPRRNSWK DPALCCDLSP EDKQINCFNT NYLRNVALVA GDTGNATGLG EQGPTRGTDA NPAPGSKEE
Research Areas
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Background

Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of oleate and palmitoleate. Oleate and palmitoleate are the main components of membrane phospholipid, triglycerides and cholesterol esters. SCD plays an important role in cellular cholesterol homeostasis and also in the secretion processes of triacylglycerol and phospholipid. Inhibition of SCD could be a useful treatment for metabollic disorders such as obesity and hepatic steatosis.

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