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Furin/PACE Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P23188 |
| Other Accession | NP_035176 |
| Reactivity | Human, Mouse, Rat, Sheep, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86772 Da |
| Gene ID | 18550 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~95-110 kDa Furin/PACE. A splice variant (~60 kDa) can also be detected. |
| Other Names | FES upstream region , FUR , FURIN , PACE , PCSK3 , SPC1 |
| Target/Specificity | Furin/PACE |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-Furin/PACE polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Furin/PACE Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Furin |
|---|---|
| Synonyms | Fur, Pcsk3 |
| Function | Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:18713856). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45) (By similarity). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (PubMed:18713856). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P09958}; Single-pass type I membrane protein. Cell membrane {ECO:0000250|UniProtKB:P09958}; Single- pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:Q28193}. Endosome membrane {ECO:0000250|UniProtKB:P09958}; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin {ECO:0000250|UniProtKB:P09958} |
| Tissue Location | Seems to be expressed ubiquitously (PubMed:2266110). Expressed in islets of Langerhans (PubMed:18713856) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Furin is a ubiquitous protein located within the trans-Golgi network. It is found in many tissues and cell lines including MDCK, HeLa, HepG2 and NIH-3T3. Furin is a proprotein convertase that is responsible for the proteolytic maturation of many precursor proteins that are secreted from the constitutive secretory pathway
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