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SCD Antibody

Rabbit Polyclonal Antibody

     
  • WB - SCD Antibody ABV10673
    Western blot analysis of SCD with rat kidney tissue lysate.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q6P7B9
Other Accession NP_114029
Reactivity Human, Mouse, Rat, Hamster, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 41013 Da
Additional Information
Gene ID 83792
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody recognizes a ~37 kDa SCD. Rat kidney tissue lysate can be used as a positive control.
Other Names stearoyl-CoA desaturase
Target/Specificity SCD
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-SCD polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSCD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Scd2
Function Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates. Important for normal permeability barrier function of the skin in neonates.
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13011}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13011}. Microsome membrane {ECO:0000250|UniProtKB:P13011}
Tissue Location Detected in brain and adipose tissue, and at much lower levels in testis. Detected in liver when rats are kept on a fat-free diet, but not when their food contains unsaturated fatty acids.
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Background

Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of oleate and palmitoleate. Oleate and palmitoleate are the main components of membrane phospholipid, triglycerides and cholesterol esters. SCD plays an important role in cellular cholesterol homeostasis and also in the secretion processes of triacylglycerol and phospholipid. Inhibition of SCD could be a useful treatment for metabollic disorders such as obesity and hepatic steatosis.

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$ 89.00
$ 245.00
Cat# ABV10673
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