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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FKBP52/Hsp56 Antibody   

FKBP52/Hsp56 Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P30416
Other Accession NP_034349
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 51572 Da
Additional Information
Gene ID 14228
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 55 kDa band in samples from human, mouse and rat origins.
Other Names FKBP4, Hsp56, FK506 binding protein 4, p52, FKBP59
Target/Specificity FKBP52/Hsp56
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFKBP52/Hsp56 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Fkbp4
Synonyms Fkpb52
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Cellular Location Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.
Research Areas
Citations (0)

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Background

FKBP52 (also known as FKBP4, Hsp56, FK506 binding protein 4, p52, FKBP59) is a 55kDa peptidyl-propyl isomerase. FKBP52 catalyzes the transition between cis- and trans- proline residues which is important in immunoregulation and proper protein folding and trafficking. FKBP52 may involve in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.

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$ 245.00
Cat# ABV10677
Size:
Quantity:
(40 western blots)
Availability: 5-7days
Bulk Size
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