|Calculated MW||51572 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 55 kDa band in samples from human, mouse and rat origins.|
|Other Names||FKBP4, Hsp56, FK506 binding protein 4, p52, FKBP59|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||FKBP52/Hsp56 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.|
|Cellular Location||Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.|
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Provided below are standard protocols that you may find useful for product applications.
FKBP52 (also known as FKBP4, Hsp56, FK506 binding protein 4, p52, FKBP59) is a 55kDa peptidyl-propyl isomerase. FKBP52 catalyzes the transition between cis- and trans- proline residues which is important in immunoregulation and proper protein folding and trafficking. FKBP52 may involve in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.
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