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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Sox-2 Antibody   

Sox-2 Antibody

Rabbit Polyclonal Antibody

  • WB - Sox-2 Antibody ABV10686
    Western blot analysis of Sox-2 in 3T3 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48431
Other Accession CAA83435
Reactivity Human, Mouse, Rat, Pig, Sheep, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 34310 Da
Additional Information
Gene ID 6657
Application & Usage Western blotting (0.5-1 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~35kDa of Sox2 in samples from mouse origins.
Other Names Sox2, Sox 2, SRY-box containing gene 2, sex determining region Y box-2, SRY related HMG box 2, Transcription factor SOX 2
Target/Specificity Sox-2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-Sox-2polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSox-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX2
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Research Areas
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Sox genes encode for transcriptional regulators that are involved in the early embryonic develpoment and in the determination of cell fate. Sox2 is also known as SRY (sex determining region Y)-box2, contain genes that encode for the HMG-box domain that is responsible for DNA binding activity. Mutation of Sox2 genes is link to optic nerve hypoplasia and anophthalmia, a severe form of eye deformity.

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$ 245.00
Cat# ABV10686
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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