|Reactivity||Human, Mouse, Rat, Pig, Sheep, Bovine, Dog|
|Calculated MW||34310 Da|
|Application & Usage||Western blotting (0.5-1 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~35kDa of Sox2 in samples from mouse origins.|
|Other Names||Sox2, Sox 2, SRY-box containing gene 2, sex determining region Y box-2, SRY related HMG box 2, Transcription factor SOX 2|
|Formulation||100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-Sox-2polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Sox-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Sox genes encode for transcriptional regulators that are involved in the early embryonic develpoment and in the determination of cell fate. Sox2 is also known as SRY (sex determining region Y)-box2, contain genes that encode for the HMG-box domain that is responsible for DNA binding activity. Mutation of Sox2 genes is link to optic nerve hypoplasia and anophthalmia, a severe form of eye deformity.
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