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>   home   >   Products   >   Primary Antibodies   >   OX40 Antibody   

OX40 Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P15725
Other Accession NP_037181
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Additional Information
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the 50 kDa full length as well as the 30 kDa and 20 kDa subunits of OX40 in Western blot analysis. Reacts with rat. Other species have not been determined.
Other Names OX 40 , OX-40, OX40 antigen, TNFRSF4, TNR4, OX40L Receptor, tumor necrosis factor receptor superfamily member 4
Target/Specificity OX40
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsOX40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tnfrsf4
Synonyms Ox40, Txgp1l
Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Activated T-cells. EMBL; X17037; CAA34897.1; -; mRNA PIR; S12783; S12783 RefSeq; NP_037181.1; NM_013049.1 UniGene; Rn.48883; - ProteinModelPortal; P15725; - SMR; P15725; - IntAct; P15725; 1 STRING; 10116.ENSRNOP00000027251; - PaxDb; P15725; - PRIDE; P15725; - Ensembl; ENSRNOT00000027251; ENSRNOP00000027251; ENSRNOG00000020106 GeneID; 25572; - KEGG; rno:25572; - CTD; 7293; - RGD; 3920; Tnfrsf4 eggNOG; ENOG410J0US; Eukaryota eggNOG; ENOG4111DUJ; LUCA GeneTree; ENSGT00730000111452; - HOGENOM; HOG000049154; - HOVERGEN; HBG005031; - InParanoid; P15725; - KO; K05142; - OMA; PIQEEHA; - OrthoDB; EOG091G03XW; - PhylomeDB; P15725; - TreeFam; TF330135; - Reactome; R-RNO-5669034; TNFs bind their physiological receptors PRO; PR:P15725; - Proteomes; UP000002494; Chromosome 5 Bgee; ENSRNOG00000020106; - Genevisible; P15725; RN GO; GO:0009986; C:cell surface; IMP:BHF-UCL GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; TAS:RGD GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central GO; GO:0006968; P:cellular defense response; TAS:RGD GO; GO:0006955; P:immune response; IBA:GO_Central GO; GO:0006954; P:inflammatory response; IBA:GO_Central GO; GO:0007275; P:multicellular organism development; IBA:GO_Central GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central GO; GO:0042098; P:T cell proliferation; IMP:BHF-UCL CDD; cd13406; TNFRSF4; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR020445; TNFR_4 InterPro; IPR034022; TNFRSF4_N Pfam; PF00020; TNFR_c6; 3 PRINTS; PR01921; TNFACTORR4 SMART; SM00208; TNFR; 3 PROSITE; PS00652; TNFR_NGFR_1; 2 PROSITE; PS50050; TNFR_NGFR_2; 2 2: Evidence at transcript level; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 19 CHAIN 20 271 Tumor necrosis factor receptor superfamily member 4 /FTId=PRO_0000034556 TOPO_DOM 20 210 Extracellular. TRANSMEM 211 235 Helical. TOPO_DOM 236 271 Cytoplasmic. REPEAT 25 60 TNFR-Cys 1 REPEAT 61 102 TNFR-Cys 2 REPEAT 103 123 TNFR-Cys 3; truncated REPEAT 124 164 TNFR-Cys 4 CARBOHYD 143 143 N-linked (GlcNAc...) asparagine DISULFID 26 37 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 38 51 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 41 59 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 62 76 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 79 94 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 82 102 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 104 122 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 125 138 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 144 163 {ECO:0000255|PROSITE-ProRule:PRU00206} SEQUENCE 271 AA; 29895 MW; C06465136B16E821 CRC64; MYVWVQQPTA FLLLGLSLGV TVKLNCVKDT YPSGHKCCRE CQPGHGMVSR CDHTRDTVCH PCEPGFYNEA VNYDTCKQCT QCNHRSGSEL KQNCTPTEDT VCQCRPGTQP RQDSSHKLGV DCVPCPPGHF SPGSNQACKP WTNCTLSGKQ IRHPASNSLD TVCEDRSLLA TLLWETQRTT FRPTTVPSTT VWPRTSQLPS TPTLVAPEGP AFAVILGLGL GLLAPLTVLL ALYLLRKAWR SPNTPKPCWG NSFRTPIQEE QTDTHFTLAK I
Citations (0)

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Background

OX40 is also known as CD134 is a member of the tumor necrosis factor receptor superfamily (TNFR). OX40 plays an important role in CD4+ and CD8+T-cells and B-cells response. Binding of OX40 to its ligand, OX40L provides co-stimulatory signal to effector T-cells without CD28 activation.

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Cat# ABV10687-30
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