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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Dectin-1 Antibody   

Dectin-1 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXN2
Other Accession EAW96155
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27627 Da
Additional Information
Gene ID 64581
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes 28 kDa of Dectin-1 from samples of human origins. A ~16 kDa monomeric form and a 43 kDa glycoprotein can also be detected. Reactivity to other species has not been tested.
Other Names DC-associated C-type lectin 1, beta-glucan receptor, C-type lectin superfamily member 12, Dectin1, Dectin 1
Target/Specificity Dectin-1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsDectin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).
Cellular Location Cell membrane; Single- pass type II membrane protein Isoform 6: Cytoplasm.
Tissue Location Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Research Areas
Citations (0)

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Dectin-1also known as beta-glucan receptor is a small type II transmembrane receptor containing lectin-like carbohydrate recognition domain. Dectin-1 plays a role in beta-glucan dependant, nonopsonic recognition of zymosan by primary macropahge. Dectin-1 is expressed on macrophages and neutrophils and on some dendritic cells subpopulation.

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$ 245.00
Cat# ABV10688
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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