|Reactivity||Human, Mouse, Rat|
|Calculated MW||27627 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes 28 kDa of Dectin-1 from samples of human origins. A ~16 kDa monomeric form and a 43 kDa glycoprotein can also be detected. Reactivity to other species has not been tested.|
|Other Names||DC-associated C-type lectin 1, beta-glucan receptor, C-type lectin superfamily member 12, Dectin1, Dectin 1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Dectin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BGR, CLECSF12, DECTIN1|
|Function||Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).|
|Cellular Location||Cell membrane; Single- pass type II membrane protein Isoform 6: Cytoplasm.|
|Tissue Location||Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Dectin-1also known as beta-glucan receptor is a small type II transmembrane receptor containing lectin-like carbohydrate recognition domain. Dectin-1 plays a role in beta-glucan dependant, nonopsonic recognition of zymosan by primary macropahge. Dectin-1 is expressed on macrophages and neutrophils and on some dendritic cells subpopulation.
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