|Reactivity||Human, Mouse, Rat|
|Calculated MW||90827 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~90-97 kDa DPP10 in samples from human, mouse and rat origins.|
|Other Names||DPP-10, DPP 10, Dipeptidyl Peptidase 10, DPPY splice variant c, dipeptidylpeptidase 10|
|Formulation||200 µg (0.5 mg/ml) affinity purified rabbit DPP10 polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||DPP10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982). Has no dipeptidyl aminopeptidase activity (Probable).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Detected in brain cortex (at protein level) (PubMed:22311982). Expressed in the brain, predominantly by neurons and not by glia.|
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Provided below are standard protocols that you may find useful for product applications.
Dipeptidyl peptidase 10 or DPP10 is a single-pass type II membrane protein that belongs to the S9B family of DPP serine proteases. The conserved serine residue which normally found in the serine proteases family is not present in DPP10. Thus, DPP10 has no detectable proteases activity as the active serine site is replaced by a glycine residue. DPP10 cleaves the terminal dipeptides from cytokines and chemokines and also facilitates the voltage-gated potassium channels. It is expressed mostly in the brain and is a potential target for asthma treatment.
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