|Reactivity||Human, Mouse, Rat|
|Calculated MW||45681 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~45 kDa unglycosylated and a >120kDa glycosylated LAMP2 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.|
|Other Names||Lysosomal-associated membrane protein 2, CD107B , Cluster of Differentiation 107B, LAMP2, LAMP-2, LAMP 2|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||LAMP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
Lysosomal-associated membrane protein 2 (LAMP2) also known as CD107B (Cluster of Differentiation 107B) is a membrane glycoprotein. LAMP2 plays an important role in the normal function of lysosome which includes protecting lysosomal membrane from autodigestion, maintaining lysosome acidity, and lysosome cellular adhesion.
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