|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||31390 Da|
|Positive Control||Western Blot: Jurkat cell lysate and 3T3 cell lysate. IHC: spleen tissue|
|Application & Usage||Western blotting (0.5-4 µg/ml) and Immunohistochemistry (5 µg/ml). It detects multiple isoforms of ICAM-2. However, the optimal concentrations should be determined individually.|
|Other Names||ICAM1 , P3.58 , BB2 , CD54|
|Formulation||100 µg (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ICAM-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Note=Co-localizes with RDX, EZR and MSN in microvilli.|
|Tissue Location||Expressed in endothelial cells and leukocytes. High levels found in lung|
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Provided below are standard protocols that you may find useful for product applications.
Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are tho µght to play an important role in embryogenesis and development. The family contains NCAM (for neuronal cell adhesion molecule), ICAM (for intercellular adhesion molecule), VCAM (vascular cell adhesion molecule), PECAM-1 (platelet/endothelial cell adhesion molecule-1), etc. ICAM-2 is involved in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.
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