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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PAK5/PAK7 Antibody   

PAK5/PAK7 Antibody

Rabbit Polyclonal Antibody

  • WB - PAK5/PAK7 Antibody ABV10716
    Western blot analysis of PAK5/PAK7 using Jurkat cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P286
Other Accession BAG53104
Reactivity Human, Mouse, Rat, Dog
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 80745 Da
Additional Information
Gene ID 57144
Application & Usage Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~80 kDa of Pak5/PAK7 from samples of human, mouse, rat and dog origins. Reactivity to other species has not been determined.

Other Names Serine/threonine-protein kinase PAK 7; p21-activated kinase 7; PAK-7; p21-activated kinase 5; PAK-5.
Target/Specificity PAK5/PAK7
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-human PAK5/PAK7 polyclonal antibody in phosphate (PBS, pH 7.2) containing 30% glycerol, 0.5 % BSA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPAK5/PAK7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAK7
Synonyms KIAA1264, PAK5
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Cellular Location Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival
Tissue Location Predominantly expressed in brain.
Research Areas
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The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. PAK 5 is known for promoting neurite outgrowth and thus predominantly expressed in the brain. PAK 5 contains CDC42/Rac1and has shown to bind CDC42 in the presence of GTP. PAK 5 also plays an important role in inhibiting apoptotic cascade thro µgh BAD phosphorylation.

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$ 245.00
Cat# ABV10716
(40 western blots)
Availability: 5-7days
Bulk Size
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