|Reactivity||Human, Mouse, Rat|
|Calculated MW||36959 Da|
|Positive Control||3T3 cell lysate|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control.|
|Other Names||melanocortin receptor 4, melanocortin 4 receptor, melanocortin-4 receptor|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-MC4 Receptor polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||MC4 Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
MC4R (Melanocortin-4 receptor) belongs to the GPCR superfamily that is responsible for multiple signal transduction pathway which includes the cAMP and MAPK signaling pathways. Expression of MC4R has been reported in brain. From genetic studies of mice and humans, it was established that MC4 receptor plays a critical role in appetite regulation. Mutation in the MC4R gene is associated with obesity in humans.
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