|Reactivity||Human, Mouse, Rat|
|Calculated MW||54700 Da|
|Positive Control||Jurkat cell lysate, Rat kidney tissue lysate|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate and rat kidney tissue lysate can be used as positive controls.|
|Other Names||Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-Adipsin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ALK-7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in interdigital regions in developing limb buds.|
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Provided below are standard protocols that you may find useful for product applications.
ALK7 or ACVR1C is a type I receptor for TGFB superfamily of signaling protein. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.
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