|Calculated MW||43146 Da|
|Positive Control||Rat kidney tissue lysate|
|Application & Usage||Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. Rat kidney tissue lysate can be used as a positive control.|
|Other Names||Beta-3 AR, beta 3-AR, Beta-3 adrenoceptor, beta3-adrenergic receptor, beta-3 adrenoreceptor|
|Formulation||200 µg (0.5 mg/ml) affinity purified rabbit anti-Beta3-AR polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Beta3-AR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||White and brown adipose tissues, and digestive tract|
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Provided below are standard protocols that you may find useful for product applications.
The neurotransmitter/hormone adrenaline (epinephrine, adrenalin) plays a central role in the mammalian stress response, increasing heart rate, raising blood pressure, and increasing blood glucose levels. Adrenaline activates both alpha-adrenergic receptors and beta-adrenergic receptors. There are mainly three subtypes of beta adrenergic receptors known, beta1, beta2, and beta3. These receptors are expressed primarily in the heart, respiratory tissue, and adipose tissue. Beta3-receptors are abundant in brown adipocytes and play vital roles in lipolysis and thermoregulation. Beta adrenergic receptors are gaining much interest among researches in the studies of type-2 diabetes mellitus and obesity. It is also being considered as a therapeutic target for heart failure.
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