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Beta3-AR Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P26255 |
| Other Accession | NP_037240.1 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43146 Da |
| Gene ID | 25645 |
|---|---|
| Positive Control | Rat kidney tissue lysate |
| Application & Usage | Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. Rat kidney tissue lysate can be used as a positive control. |
| Other Names | Beta-3 AR, beta 3-AR, Beta-3 adrenoceptor, beta3-adrenergic receptor, beta-3 adrenoreceptor |
| Target/Specificity | AR-Beta3 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 200 µg (0.5 mg/ml) affinity purified rabbit anti-Beta3-AR polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Beta3-AR Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Adrb3 |
|---|---|
| Synonyms | Adrb3r |
| Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | White and brown adipose tissues, and digestive tract |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The neurotransmitter/hormone adrenaline (epinephrine, adrenalin) plays a central role in the mammalian stress response, increasing heart rate, raising blood pressure, and increasing blood glucose levels. Adrenaline activates both alpha-adrenergic receptors and beta-adrenergic receptors. There are mainly three subtypes of beta adrenergic receptors known, beta1, beta2, and beta3. These receptors are expressed primarily in the heart, respiratory tissue, and adipose tissue. Beta3-receptors are abundant in brown adipocytes and play vital roles in lipolysis and thermoregulation. Beta adrenergic receptors are gaining much interest among researches in the studies of type-2 diabetes mellitus and obesity. It is also being considered as a therapeutic target for heart failure.
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