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Pyruvate Dehydrogenase Phosphatase 2 (PDP2) Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9P2J9 |
| Other Accession | NP_065837.1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59978 Da |
| Gene ID | 57546 |
|---|---|
| Positive Control | Jurkat cell lysate, 3T3 cell lysate |
| Application & Usage | Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat or 3T3 cell lysate can be used as a positive control. |
| Other Names | pyruvate dehydrogenase (lipoamide) E1 component, beta subunit precursor; pyruvate decarboxylase.; pyruvate dehydrogenase, Pyruvic dehydrogenase, Sphingobacterium spiritivorum ATCC 33861 |
| Target/Specificity | PDP2 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 200 µg (0.5 mg/ml) affinity purified rabbit anti-PDPC polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Pyruvate Dehydrogenase Phosphatase 2 (PDP2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDP2 (HGNC:30263) |
|---|---|
| Synonyms | KIAA1348 |
| Function | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity). |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:O88484}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PDP2, Pyruvate dehydrogenase phosphatase 2, catalyzes the dephosphorylation and activation of E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex.
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