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TORC2 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q3LRZ1
Other Accession NP_001029067.1
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 73146 Da
Additional Information
Gene ID 310615
Positive Control Rat kidney tissue lysate
Application & Usage The antibody can be used for Western blotting (0.5–4 µg/ml).
Other Names CREB-regulated transcription coactivator 2; transducer of regulated cAMP response element-binding protein 2; TORC-2; transducer of CREB protein 2
Target/Specificity TORC2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-TORC2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTORC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Crtc2
Synonyms Torc2
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus (By similarity).
Citations (0)

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Torc2 (transducer of regulated CREB activity 2) is a key regulator of fasting glucose metabolism. Sequestered in the cytoplasm under feeding conditions, TORC2 is dephosphorylated and transported to the nucleus where it enhances CREB-dependent transcription in response to fasting stimuli.

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$ 245.00
Cat# ABV10741
(40 western blots)
Availability: 5-7days
Bulk Size
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