|Calculated MW||73146 Da|
|Positive Control||Rat kidney tissue lysate|
|Application & Usage||The antibody can be used for Western blotting (0.5–4 µg/ml).|
|Other Names||CREB-regulated transcription coactivator 2; transducer of regulated cAMP response element-binding protein 2; TORC-2; transducer of CREB protein 2|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-TORC2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TORC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Torc2 (transducer of regulated CREB activity 2) is a key regulator of fasting glucose metabolism. Sequestered in the cytoplasm under feeding conditions, TORC2 is dephosphorylated and transported to the nucleus where it enhances CREB-dependent transcription in response to fasting stimuli.
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