Rictor Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q6QI06 |
Other Accession | NP_084444 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 191570 Da |
Gene ID | 78757 |
---|---|
Positive Control | Jurkat, HeLa, 3T3 cell lysates |
Application & Usage | The antibody can be used for Western blotting (1–4 µg/ml). |
Other Names | RICTOR; DKFZp686B11164; KIAA1999; MGC39830; mAVO3 |
Target/Specificity | Rictor |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 200 µg (0.5 mg/ml) affinity purified rabbit anti-Rictor polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Rictor Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Rictor {ECO:0000312|MGI:MGI:1926007} |
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Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. |
Tissue Location | Highest levels in liver and brain with expression also detected in heart, muscle, spleen and kidney (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rictor is a component of a protein complex [mTORC2] that integrates nutrient- and growth factor-derived signals to regulate cell growth. Rictor also plays an essential role in Akt phosphorylation and signaling.
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