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Anti-Human Myeloperoxidase (MPO) Antibody (Clone 03D03)

Mouse Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, E
Primary Accession P05164
Other Accession EAW94472.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1κ
Clone Names 03D03
Calculated MW 83869 Da
Additional Information
Gene ID 4353
Application & Usage Myeloperoxidase Sandwich ELISA. This pair is able to detect MPO at < 3 ng/ml.
Other Names 89 kDa myeloperoxidase, 84 kDa myeloperoxidase, Myeloperoxidase light chain, Myeloperoxidase heavy chain
Target/Specificity MPO
Antibody Form Liquid
Appearance Colorless liquid
Formulation 0.15 M PBS
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-Human Myeloperoxidase (MPO) Antibody (Clone 03D03) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MPO
Function Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
Cellular Location Lysosome.
Research Areas
Citations (0)
citation

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Background

Myeloperoxidase (MPO) is highly expressed in neutrophils and polymorphonuclear luekocytes. MPO is expressed as a dimer in regular neutrophils with a 140 kDA. The glycosylated form of MPO has a molecular weight of 92 kDa and when undergoes a final glycosylation, MPO forms subunits of 60 kDa and 12 kDa. In recent studies, MPO was shown to be involved in the initiation and progression of cardiovascular disease.

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Discontinued
Cat# ABV10776-100
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