|Application ||FC, E|
|Calculated MW||83869 Da|
|Application & Usage||Myeloperoxidase Sandwich ELISA. This pair is able to detect MPO at < 3 ng/ml.|
|Other Names||89 kDa myeloperoxidase, 84 kDa myeloperoxidase, Myeloperoxidase light chain, Myeloperoxidase heavy chain|
|Formulation||0.15 M PBS|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Anti-Human Myeloperoxidase (MPO) Antibody (Clone 12D06) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.|
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Provided below are standard protocols that you may find useful for product applications.
Myeloperoxidase (MPO) is highly expressed in neutrophils and polymorphonuclear luekocytes. MPO is expressed as a dimer in regular neutrophils with a 140 kDA. The glycosylated form of MPO has a molecular weight of 92 kDa and when undergoes a final glycosylation, MPO forms subunits of 60 kDa and 12 kDa. In recent studies, MPO was shown to be involved in the initiation and progression of cardiovascular disease.
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