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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FGF-1 Antibody   

FGF-1 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05230
Other Accession NP_000791
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 17460 Da
Additional Information
Gene ID 2246
Application & Usage Western blot analysis (0.5-2 µg/ml). Per researchers feedback, it also works well in ELISA (2-3 µg/ml), and neutralization (3-6 µg/ml). However, the optimal conditions should be determined individually.
Other Names FGF1, FGF-1, FGF 1, Fibroblast Growth Factor 1, FGF 1, FGF1, Heparin-binding growth factor 1, HBGF-1, Acidic fibroblast growth factor, aFGF, Putative heparin-binding growth factor 1, Alpha-endothelial cell growth factor, Endothelial cell growth factor alpha
Target/Specificity FGF-1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti- human FGF-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFGF-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGF1
Synonyms FGFA
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Cellular Location Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Tissue Location Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle
Research Areas
Citations (0)

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FGF-1 is an acidic heparin binding growth factor that stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. Human FGF-1 is a 15.8 kDa protein containing 140 amino acid residues.

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$ 245.00
$ 89.00
Cat# ABV10785
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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