IL-17A Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC, E |
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Primary Accession | Q16552 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 17504 Da |
Gene ID | 3605 |
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Positive Control | ELISA: Recombinant hIL-17A IHC: Human breast invasive ductal carcinoma tissue section |
Application & Usage | 1) WB: Use 0.1-0.2 µg/ml. The detection limit for recombinant human IL-17A is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 2) ELISA: Use 0.5 - 2.0 µg/ml (100 µl/well antibody solution) 3) Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hIL-17A (50.0 ng/ml), a concentration of 0.9-1.3 µg/ml of this antibody is required. 4) Immunohistochemistry: 0.25 µg/ml with an overnight incubation at 4°C. |
Other Names | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte associated antigen 8 |
Target/Specificity | IL-17A |
Antibody Form | Liquid |
Appearance | Liquid |
Formulation | A sterile filtered antibody solution in PBS, pH 7.2. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | IL-17A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IL17A |
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Synonyms | CTLA8, IL17 |
Function | Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). |
Cellular Location | Secreted. |
Tissue Location | Restricted to activated memory T-cells. |

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Provided below are standard protocols that you may find useful for product applications.
Background
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells.

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