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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q16552 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17504 Da |
| Gene ID | 3605 |
|---|---|
| Positive Control | ELISA: Recombinant hIL-17A IHC: Human breast invasive ductal carcinoma tissue section |
| Application & Usage | 1) WB: Use 0.1-0.2 µg/ml. The detection limit for recombinant human IL-17A is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 2) ELISA: Use 0.5 - 2.0 µg/ml (100 µl/well antibody solution) 3) Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hIL-17A (50.0 ng/ml), a concentration of 0.9-1.3 µg/ml of this antibody is required. 4) Immunohistochemistry: 0.25 µg/ml with an overnight incubation at 4°C. |
| Other Names | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte associated antigen 8 |
| Target/Specificity | IL-17A |
| Antibody Form | Liquid |
| Appearance | Liquid |
| Formulation | A sterile filtered antibody solution in PBS, pH 7.2. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | IL-17A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL17A |
|---|---|
| Synonyms | CTLA8, IL17 |
| Function | Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). |
| Cellular Location | Secreted. |
| Tissue Location | Restricted to activated memory T-cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells.
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