|Calculated MW||30607 Da|
|Application & Usage||Western blot analysis (0.5-2 µg/ml). Per researcher’s feedback, it can also be used in neutralization (5-10 µg/ml). However, the optimal conditions should be determined individually. Recombinant human IL-1α can be used as a positive control.|
|Other Names||IL-1, IL1, IL 1, Interluekin-1 alpha, Interluekin 1 alpha, interluekin|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human IL-1α polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||IL-1 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.|
|Cellular Location||Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins|
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Provided below are standard protocols that you may find useful for product applications.
IL-1α is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses. Human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.
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