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IL-6 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P08505 |
| Other Accession | NP_112445 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24384 Da |
| Gene ID | 16193 |
|---|---|
| Application & Usage | Western Blotting (0.5-4.0 µg/ml). Per researcher’s feedback the antibody also works well in Neutralization (2-4 µg/ml). However, the optimal condition should be determined individually. |
| Other Names | IL-6, IL6, IL 6, Interluekin-6, Interluekin 6, interluekin |
| Target/Specificity | IL-6 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-murine IL-6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | IL-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Il6 {ECO:0000312|MGI:MGI:96559} |
|---|---|
| Synonyms | Il-6 |
| Function | Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism (Probable). Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (PubMed:8910279). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (PubMed:27893700). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed by dendritic cells and macrophages (PubMed:27893700, PubMed:23045607). Expressed by activated follicular B cells (PubMed:23045607). Abundantly expressed in the central nervous system (CNS), particularly the hypothalamic region (PubMed:28402851) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
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