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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IP-10 Antibody   

IP-10 Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P48973
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 10729 Da
Additional Information
Gene ID 245920
Application & Usage Western Blot analysis (0.5-1.0 µg/ml), Neutralization (10 µg/ml), and ELISA (2-4 µg/ml). However, the optimal condition should be determined individually.
Other Names IP-10, IP10, IP 10, Cxcl10, CXCL10, CXCL-10, CXCL 10, C-X-C motif chemokine 10, Small-inducible cytokine B10; 10 kDa interferon-gamma-induced protein; Gamma-IP10; IP-10
Target/Specificity IP-10
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) purified rabbit anti-rat IP-10 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsIP-10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cxcl10
Synonyms Inp10, Mob1, Scyb10
Function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity) (PubMed:30257241, PubMed:30448292).
Cellular Location Secreted {ECO:0000250|UniProtKB:P02778}.
Tissue Location In the central nervous system, CXCL10 is predominantly localized to activated neurons (PubMed:30448292) Expressed in both microglia and astrocytes (PubMed:30257241)
Research Areas
Citations (0)
citation

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Background

Human IP-10 is an 8.5 kDa protein produced by several cell types during the delayed type hypersensitivity response. IP-10 acts as a chemoattractant towards monocytes, lymphocytes, and certain T cells.

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Discontinued
Cat# ABV10869-100
Size:

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