|Application ||WB, IHC, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||10254 Da|
|Positive Control||Western Blot: Jurkat cell lysate and 3T3 cell lysate. IHC: Kidney tissue|
|Application & Usage||Western blot analysis (0.5-4 µg/ml), Immunoprecipitation (3-5 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||GRO alpha, GRO, chemokine (C-X-C), KC|
|Formulation||100 µg (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||KC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Gro, Gro1, Mgsa, Scyb1|
|Function||Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.|
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Provided below are standard protocols that you may find useful for product applications.
KC, a homolog of human and hamster gro/MGSA, is a 72-amino acid CXC chemokine originally cloned from rat macrophages and lung tissue. It is the mediator for recruitment and activation of netrophils in rat lung inflammation models. Expression of KC can be upregulated by LPS and IL-1β stimulation. IFN-g blocks LPS-induced expression of KC.
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