|Calculated MW||22008 Da|
|Application & Usage||The antibody can be used for Western blot analysis (0.5-1 µg/ml), ELISA (2-3 µg/ml), and neutralization (0.5-1 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||LIF; CDF; D-FACTOR; HILDA|
|Formulation||100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-human LIF polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||LIF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|
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Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, tho µgh mouse LIF is about 1000 fold less active on human cells, than human LIF.
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