Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
MIP-1-alpha Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | P50229 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 10335 Da |
| Gene ID | 25542 |
|---|---|
| Application & Usage | Western blot analysis (0.5-4 µg/ml) and immunoprecipitation (4-8 µg/ml). However, the optimal conditions should be determined individually. |
| Other Names | MIP-1, MIP1, MIP 1, MIP-1a, MIP 1a, MIP 1 alpha, macrophge inhibitory protein-1 alpha, macrophge inhibitory protein 1 alpha, macrophge inhibitory protein |
| Target/Specificity | MIP-1a |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-rat MIP-1α polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | MIP-1-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ccl3 |
|---|---|
| Synonyms | Mip1a, Scya3 |
| Function | Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
MIP-1α (macrophage inflammatory protein-1α is a 60-amino acid CC chemokine with a molecular weight of 7.9 kDa. MIP-1α induces migration of monocytes/macrophages, B-lymphocytes, activated CD8+ T cells, natural killer (NK) cells, eosinophils. MIP-1α also stimulates basophils to release histamine, induces ICAM-1 expression, mast cell degranulation, and production of TNF-α, IL-1 and IL-6. In addition to its proinflammatory activities, MIP-1α inhibits the proliferation of hematopoietic stem cells in vitro and in vivo.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
