|Application ||WB, IP|
|Calculated MW||10335 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml) and immunoprecipitation (4-8 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||MIP-1, MIP1, MIP 1, MIP-1a, MIP 1a, MIP 1 alpha, macrophge inhibitory protein-1 alpha, macrophge inhibitory protein 1 alpha, macrophge inhibitory protein|
|Formulation||100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-rat MIP-1α polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||MIP-1-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
MIP-1α (macrophage inflammatory protein-1α is a 60-amino acid CC chemokine with a molecular weight of 7.9 kDa. MIP-1α induces migration of monocytes/macrophages, B-lymphocytes, activated CD8+ T cells, natural killer (NK) cells, eosinophils. MIP-1α also stimulates basophils to release histamine, induces ICAM-1 expression, mast cell degranulation, and production of TNF-α, IL-1 and IL-6. In addition to its proinflammatory activities, MIP-1α inhibits the proliferation of hematopoietic stem cells in vitro and in vivo.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.