|Application ||WB, E|
|Calculated MW||17006 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). Recombinant human TGF-a can be used as a positive control. However, the optimal conditions should be determined individually.|
|Other Names||TGF-a, TGF-alpha, TGF alpha, TGFalpha, transforming growth factor alpha, EGF-like TGF, ETGF, TGF type 1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human TGF-α polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TGF-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.|
|Cellular Location||Transforming growth factor alpha: Secreted, extracellular space|
|Tissue Location||Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Transforming Growth Factor-alpha (TGF-α) stimulates the proliferation of a wide range of epidermal and epithelial cells. TGF-α has been shown to play a role in the autocrine growth of certain transformed cells.
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