TGF-alpha Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P01135 |
Other Accession | NP_003227 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 17006 Da |
Gene ID | 7039 |
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Application & Usage | Western blot analysis (0.5-4 µg/ml). Recombinant human TGF-a can be used as a positive control. However, the optimal conditions should be determined individually. |
Other Names | TGF-a, TGF-alpha, TGF alpha, TGFalpha, transforming growth factor alpha, EGF-like TGF, ETGF, TGF type 1 |
Target/Specificity | TGF-a |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-human TGF-α polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TGF-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TGFA |
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Function | TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
Cellular Location | [Transforming growth factor alpha]: Secreted, extracellular space |
Tissue Location | Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transforming Growth Factor-alpha (TGF-α) stimulates the proliferation of a wide range of epidermal and epithelial cells. TGF-α has been shown to play a role in the autocrine growth of certain transformed cells.
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