|Calculated MW||22297 Da|
|Application & Usage||Western blot analysis (0.5-1 µg/ml) and Neutralization (2-5 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||TNF-b, TNF b, TNFbeta, tnf, tumor necrosis factor, tumor necorsis factor beta, TNF superfamily member 2, Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; Flags: Precursor.|
|Formulation||100 µg (0.5 mg/ml) purified rabbit anti-human TNF-β polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol and 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TNF-beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.|
|Cellular Location||Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated|
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Provided below are standard protocols that you may find useful for product applications.
Tumor Necrosis Factor-beta (TNF-β) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Human TNF-β is an 18.6 kDa protein containing 171 amino acid residues.
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