TNF-R1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P19438 |
Other Accession | BAG51763 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 50495 Da |
Gene ID | 7132 |
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Application & Usage | Western blot analysis (0.5-4 µg/ml). Recombinant human sTNF-RI can be used as a positive control. Per researcher’s feedback, the antibody can also be used in neutralization. However, the optimal conditions should be determined individually. |
Other Names | TNF-R1, Tumor Necrosis Factor type I, TNFRSF1A, TNFAR, TNF-R55, TNFR60, p55, CD120a |
Target/Specificity | TNF-RI |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-human sTNF-RI polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TNF-R1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFRSF1A |
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Synonyms | TNFAR, TNFR1 |
Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
Cellular Location | Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tumor Necrosis Factor receptor type I (TNF-RI) is also referred as p60. The p60 form of the receptor is primarily expressed on epithelial cells. Recombinant Human soluble TNF receptor Type I (sTNF-RI) is a 18.3 kDa protein containing 162 amino acid residues comprising the extra cellular domain of TNF Receptor Type I.
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