|Application ||WB, E|
|Calculated MW||110962 Da|
|Positive Control||Western Blot: Human liver tissue lysate|
|Application & Usage||Western Blot: 1 µg/ml, ELISA. However, the optimal conditions should be determined individually.|
|Other Names||Storkhead-box protein 1, C10orf24, winged-helix domain-containing protein, PEE4|
|Formulation||100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||STOX1 Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Isoform A: Cytoplasm. Nucleus. Note=Either found in the cytoplasm or in the nucleus. Nuclear expression of isoform A seems to be restricted to polyploid trophoblast cells Isoform C: Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.
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