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STOX1 Antibody (CT)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZVD7 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG1 |
| Calculated MW | 110962 Da |
| Gene ID | 219736 |
|---|---|
| Positive Control | Western Blot: Human liver tissue lysate |
| Application & Usage | Western Blot: 1 µg/ml, ELISA. However, the optimal conditions should be determined individually. |
| Other Names | Storkhead-box protein 1, C10orf24, winged-helix domain-containing protein, PEE4 |
| Target/Specificity | STOX1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | STOX1 Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STOX1 |
|---|---|
| Synonyms | C10orf24 |
| Function | Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). |
| Cellular Location | [Isoform A]: Cytoplasm. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosomes during metaphase (PubMed:22253775). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:22253775} [Isoform C]: Nucleus, nucleolus. |
| Tissue Location | Expressed in placenta, including the invasive extravillus trophoblast cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.
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