BLC Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O55038 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 11927 Da |
Gene ID | 55985 |
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Application & Usage | Western blot (at 0.5-4 µg/ml). However, the optimal conditions should be determined individually. |
Other Names | B-lymphocyte chemoattractant |
Target/Specificity | BLC |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) Protein A purified rabbit anti-BLC polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | BLC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Cxcl13 |
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Synonyms | Blc, Scyb13 |
Function | Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B- lymphocytes to follicles in secondary lymphoid organs. |
Cellular Location | Secreted. |
Tissue Location | Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles) |
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Provided below are standard protocols that you may find useful for product applications.
Background
BLC (B-lymphocyte chemoattractant) is a 12 kDa ELR-CXC chemokine. BLC showed high levels of expression in spleen, Peyer’s patches, and mesenteric lymph nodes. BLC is reported as the ligand of CXCR5. It attracts primarily B cells in vitro. Cell lines transfected with CXCR5 demonstrate both chemotaxis and calcium flux in response to BLC.
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